Pharmacological studies of 5-n-butyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP), a new anti-inflammatory agent
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چکیده
منابع مشابه
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
A series of novel 3-cyclohexyl-2-substituted hydrazino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material, 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one, was synthesized from cyclohexyl amine. Title compounds were investigated for analgesic, anti-inflammatory and ulcer...
متن کاملSynthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles
N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...
متن کامل[1-(4-Nitrobenzyl)-2-butyl-4-chloro-1H-imidazol-5-yl]-4, 5-dihydro-1-phenyl-1H-pyrazole: Synthesis, Anti-Inflammatory and Analgesic Activities
In the present investigation, series of Bis (heterocycle)s bearing pyrazoline in combination of the imidazole derivatives have been synthesized via 1,3-dipolar cycloaddition reactions of N-(nitrobenzyl)-imidazole nitrile imines with different dipolarophiles. All the newly synthesized compounds were characterized and screened for analgesic-anti-inflammatory activities and were compared with the ...
متن کاملN-Butyl-4-methyl-6-phenylpyrimidin-2-amine
In the title compound, C(15)H(19)N(3), the pyrimidine ring is approximately planar [maximum deviation = 0.007 (1) Å] and forms a dihedral angle of 3.15 (6)° with the benzene ring. In the crystal packing, inter-molecular N-H⋯N hydrogen bonds link pairs of neighbouring mol-ecules into dimers with R(2) (2)(8) ring motifs. These dimers are stacked along the b axis.
متن کاملN′-tert-Butyl-5-(4-chlorophenyl)furan-2-carbohydrazide
In the title mol-ecule, C(15)H(17)ClN(2)O(2), the furan and benzene rings form a dihedral angle of 15.35 (8)°. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains extended in the [010] direction.
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1967
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.63.43